Oral administration :
Administer 30 minutes before each meal and at bedtime.
Parenteral administration :
- Metoclopramide is administered by IM or direct IV injection, or
by IV infusion.
- Inject each 10 mg of metoclopramide IV push over 1-2 minutes.
Intravenous infusion:
Dilute in 50 ml of NS, D5W, Ringer's, or lactated Ringer's
injection. Metoclopramide is most stable when diluted with NS injection. Infuse
IV slowly over at least 15 minutes.
For the prevention of post-operative nausea/vomiting:
Parenteral dosage:
Adults: 10 mg IM or IV near the end of the surgical procedure.
May be repeated every 4-6 hours as necessary. If required, a 20 mg dose may be
used.
Children(*): 0.1-0.2 mg/kg IV. May be repeated every 6-8 hours,
as needed. A dose of 0.25 mg/kg IV has also been used and is frequently given
after inhalation anesthesia.
For prevention of nausea/vomiting induced by cancer chemotherapy:
Intravenous infusion:
Adults: 1-2 mg/kg IV 30 minutes before administration of
antineoplastic therapy. May be repeated twice at 2-hourly intervals. If vomiting
continues, 3 further doses may be given at 3-hourly intervals. After vomiting
has been suppressed, a maintenance dose of 1 mg/kg may be given, at 3-hourly
intervals for 3 additional doses.
For the treatment of diabetic gastroparesis:
Oral, intravenous or intramuscular dosage:
Adults: 10 mg PO qid, 30 minutes before food and at bedtime. If
symptoms are severe the IV or IM route may be used to initiate therapy.
For use as a diagnostic aid during gastrointestinal radiography
and to facilitate intestinal intubation:
Intravenous dosage:
Adults: 10 mg as a single IV injection.
Children age 6-14 years: 2.5-5 mg as a single IV injection, dose
should not exceed 0.5 mg/kg/day.
Children 6 years and under: 0.1 mg/kg IV, dose should not exceed
0.5 mg/kg/day.
For treatment of gastroesophageal reflux disease (GERD):
Oral dosage:
Adults: 10-15 mg PO up to qid, 30 minutes before food and at
bedtime. Elderly patients may respond to a dose of 5 mg. Therapy for more than
12 weeks is not recommended.
Infants and children: 0.4-0.8 mg/kg/day in 4 divided doses. Same
dose may also be given IM or IV.
For the treatment of acute, severe migraine(*) prior to
administration of dihydroergotamine (DHE) to offset DHE-induced nausea; or in
patients who do not respond to dihydroergotamine:
Parenteral dosage:
Adults: 10 mg IM or by IV push.
For the treatment of persistent hiccups(*) (singultus):
Oral/Parenteral dosage:
Adults: Metoclopramide 10 mg IV/IM has been given for persistent
or intractable hiccup. If hiccups are relieved, maintenance therapy of 10-20 mg
PO/IM/IV for at least 10 days is recommended.
Patients with renal impairment:
CrCl > 40 ml/min: no dosage adjustment needed.
CrCl < 40 ml/minute: reduce recommended dose by 50%.
