Losartan-H is administrated orally with or without food.
Oral Dosage :
Adults : initially, 50/12.5 mg PO once daily. Dosage range is
50/12.5-100/25 mg/day PO administered daily, or as directed by physician.
Contraindications :
Breast-feeding, pregnancy, children and sever hepatic impairment.
Cautions :
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In heart-failure patient may cause oliguria and progressive azotemia.
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Hepatic diseases, patients with cirrhosis demonstrated significantly increased
plasma concentrations compared to normal patients. Dosage adjustment in this
population is recommended.
-
Hypovolemia in these patients, lower doses are recommended (see dosage)
-
In renal artery stenosis patient may cause oliguria and progressive azotemia.
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Hydrochlorothiazide and related diuretics may exacerbate diabetes, gout and
systemic lupus erythematosus. Electrolytes should be monitored particularly with
high doses, long-term use, or in renal impairment. Hydrochlorothiazide and
related diuretics should also be used with caution in nephrotic syndrome,
hyperaldosteronism, malnourishment.
Drug
interaction :
Losartan has no specific interaction information.
Losartan belongs to Angiotensin II receptor antagonists
and will have the following interactions :
Potassium salts, lithium, potassium sparing, diuretics, cyclosporine, alcohol,
baclofen, clonidine, heparine, levodopa, methyldopa, minoxidil, anxiolytics and
hypnotics ….. etc.
Hydrochlorothiazide has the following drug interactions :
Alcohol, barbithurates, oral anti-diabetics agent, cholestyramine,
corticosteroids, tubocurarine, amantadine, colestipol, diazoxide, digoxin,
lithium, NSAIDs.
