- (Clopidogrel) is usually taken once
daily with or without food.
Contraindications :
- (Clopidogrel) is contraindicated in:
* Hypersensitivity to Clopidogrel.
* Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
* Children under 18 years.
Precautions :
- (Clopidogrel) should be used with
caution in :
* Patients with high risk of increase bleeding, e.g. trauma, surgery or other
pathological conditions. If patient is to undergo to selective surgery and an
anti-platelet effect is not desired, (Clopidogrel) should be discontinued 7days
prior to surgery.
* Patients with severe hepatic disease who may have bleeding diatheses.
Drug interaction :
- (Clopidogrel) is contraindicated
with :
Aspirin and other NSAIDs, warfarin, phenytoin, tamoxifen, tolbutamide, torsemide,
fluvastatin.
- Simultaneous chronic use of with :
* Aspirin, other NSAIDs and warfarin:
may increases bleeding time.
* Phenytoin, tamoxifin and tolbutamide :
may increases the serum concentration of these drugs.
Side effects :
Chest pain, accidental injury, influenza-like symptoms, pain, fatigue, edema,
hypertension, headache, dizziness, abdominal pain, dyspepsia, nausea,
hypercholesterolemia, arthralgia, back pain, purpura, epistaxis, depression,
upper respiratory tract infections, dyspnea, rhinitis, coughing, rash, pruritus.
Instructions to the patients :
- (Clopidogrel) should be swallowed
with a drink of water.
- Tell your physician about all other medicines your are taking.
- Tell your physician if you have blood from vomiting, black tarry stool (blood
in stool), blood in urine, stomach pain, purple spots on the skin (bleeding
under skin), unusually heavy menstrual bleeding.
- Tell your physician of dentist that you are taking (Clopidogrel).
